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Diaper rash can best be prevented if the toddler's bottom is washed with soap and water after every messy diaper. Diaper wipes don't completely clean all the irritants from a toddler's bottom. Give your toddler a quick bath after a messy diaper. If you don't have time to give your toddler a quick bath, try adding a little soap and extra water to the last diaper wipe used to clean your toddler's bottom.